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  • The U.S. Food and Drug Administration has approved the usage of Contrave (naltrexone hydrochloride and bupropion hydrochloride extended-release tablets) to assist manage chronic obesity in older adults with a body mass index (BMI) of greater than 27, given that they also suffer from weight-related health issues such as Tupe2 diabestes, high-cholesterol and/or hypertension (high blood pressure).Contrave is really a combination of two FDA-approved drugs, naltrexone and bupropion, in an extended-release formulation. Naltrexone qualifies to treat alcohol and opioid dependence. Bupropion is eligible to treat depression and seasonal affective disorder in addition to being an aid to smoking cessation treatment.'Obesity is still a major public health concern,' said Jean-Marc Guettier, M.D., director of the Division of Metabolism and Endocrinology Products in FDA's Center for Drug Evaluation and Research. 'When used as directed in combination having a healthy lifestyle that includes a reduced-calorie dieting and exercise, Contrave provides another treatment selection for chronic weight reduction for people who are obese or are overweight and also have at least one weight-related health issue.'The drug's effectiveness was evaluated in multiple numerous studies that included approximately 4,500 obese and overweight patients with and without significant weight-related conditions treated first year. All patients received lifestyle modification that consisted of a reduced- calorie diet and regular exercise. Results from a clinical study that enrolled patients without diabetes showed that patients had an average weight loss of 4.1% instead of participants who have been given placebos) after a 12- month period, while an outside study involving patients with diabetes type 2 symptoms had a normal weight loss of 2% over treatment with placebo at one full year.

    Using two separate drugs to shed pounds can be very effective you can find combinations before the FDA now awaiting approval. When dealing with fat loss and the people that go through it you should err to the side of caution and allow the FDA do its job and demand some research be done so the public recognizes the side effects and perils associated with the medications before we drive them. Keep in mind that drug companies will be in business to earn money and that they would say almost anything to keep people on their medications.

    Researchers discovered that participants taking this drug for the year, lost excess weight within four weeks and have kept the extra weight off through the entire 56 weeks from the study. Contrave is really a combination from the drugs naltrexone and bupropion, which appears to reflect a new trend of weight-loss drugs which can be made up of several active ingredient, which might make them more potent and safer.

    Combo-pilling is the newest fad or in addition to this the newest ahead under scrutiny and thus it is just more publicly known in recent months, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills is becoming popular will be the fact that as of right now there are no long term prescription weight loss supplements that have been approved by the FDA besides orlistat. The truly disturbing part is doctors are prescribing these combinations of medications and some of the combinations have been rejected or have yet to be approved by the FDA.

    Seizures really are a side effect with Contrave and shouldn't be taken in those with seizure disorders. The drug may also raise blood pressure levels and pulse rate, and really should not be used in individuals with a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with the drug.

    The FDA also warned that Contrave can raise hypertension and heart rate and must 't be used in patients with uncontrolled high hypertension, in addition to by you are not heart-related and cerebrovascular (circulatory dysfunction impacting your brain) disease. Patients with a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients to the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stopping smoking.

    Other people who must avoid using Contrave are patients struggling with bulimia, anorexia nervosa, anyone using opiods, and patients undergoing an 'abrupt discontinuation of alcohol, benzodiazepines, barbiturates and antiepileptic drugs.' Lastly Concave shouldn't be prescribed for females who are pregnant or looking to become pregnant.